Gru and Lucy are settling into life with Margo, Edith, Agnes, and the newest member of the family, Gru Jr., a baby who seems determined to make his dad’s life difficult. But family chaos is only the beginning when Gru is targeted by a new enemy, Maxime Le Mal, and his girlfriend Valentina. With danger closing in, the whole Gru family is forced to leave home and go on the run.