Nick Daley is not sure he is ready to follow in his father’s footsteps as the night watchman at the American Museum of Natural History. He already knows that the museum is very different after the sun goes down, but his first nights on the job become far more dangerous when the maniacal ruler Kahmunrah escapes and sets out to conquer the world. Now Nick must protect the museum and stop Kahmunrah before it is too late.